Alentis Therapeutics Doses First ANCA-Associated Vasculitis Rapidly Progressive Glomerulonephritis Patient in Phase 2 Clinical Trial of Lixudebart (ALE.F02)
The Study Evaluates the Safety and Renal Sparing Efficacy of Lixudebart Basel, Switzerland – Dec 5, 2023, Alentis Therapeutics (“Alentis”), a clinical-stage biotechnology company developing treatments for Claudin-1 positive (CLDN1+) tumors and organ fibrosis, announced today the first patient dosed in a Phase 2 clinical trial of lixudebart (formerly named ALE.F02), a Claudin-1 (CLDN1) targeting investigational antibody for the treatment of organ fibrosis.The randomized, double-blind, placebo-controlled Phase 2 study (NCT06047171) of lixudebart evaluates the drug’s safety, tolerability, pharmacokinetics, and how well it protects against the loss of kidney function. The study plans to recruit patients with Antineutrophil Cytoplasmic Antibody…